W4262

1400W dihydrochloride

>98%, solid

• Synonyme(s) : N-([3-(aminomethyl)phenyl]methyl)ethanimidamide dihydrochloride
• Formule empirique (notation de Hill): C₁₀H₁₅N₃ · 2 HCl
• Numéro CAS: 214358-33-5
• Poids moléculaire : 250.17
• Numéro MDL: MFCD03428622
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278778
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: >98%
• Forme: solid
• Conditions de stockage: desiccated
• Auteur: GlaxoSmithKline
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1
• InChI: 1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
• Clé InChI: WDJHSQZCZGPGAA-UHFFFAOYSA-N
• Informations sur le gène: human ... NOS1(4842) , NOS2(4843) , NOS3(4846)

Description

Application

1400W dihydrochloride has been used:

• as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
• as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
• to study its efficacy on renal ischemia/ reperfusion injury in rats
• as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation

Actions biochimiques/physiologiques

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Caractéristiques et avantages

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)