T4626

N_α-p-Tosyl-L-arginine methyl ester hydrochloride

≥98% (TLC), suitable for ligand binding assays

• Synonyme(s) : TAME hydrochloride
• Formule linéaire : H₂NC(=NH)NH(CH₂)₃CH(NHSO₂C₆H₄CH₃)CO₂CH₃ · HCl
• Numéro CAS: 1784-03-8
• Poids moléculaire : 378.87
• NACRES: NA.26
• PubChem Substance ID: 24900058
• eCl@ss: 32160406
• UNSPSC Code: 12352103
• EC Number: 217-235-1
• MDL number: MFCD00012578
• Beilstein/REAXYS Number: 3922357

Propriétés

• Nom du produit: N_α-p-Tosyl-L-arginine methyl ester hydrochloride,
• assay: ≥98% (TLC)
• Quality Segment: 200
• form: powder
• technique(s): ligand binding assay: suitable
• color: white
• mp: 145-147 (lit.)
• storage temp.: −20°C
• SMILES string: Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1
• InChI: 1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1
• InChI key: JIQFFACVQXXHMY-YDALLXLXSA-N

Description

General description

Substrate for trypsin, thrombin, plasmin, and other proteases.

Application

Nα-p-Tosyl-L-arginine methyl ester hydrochloride has been used as an esterolytic substrate to assess trypsin-like activity in midgut extracts. It has also been used as a substrate for measuring trypsin activity of pancreatin and human intestinal samples.

Biochem/physiol Actions

N_α-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)