T4382

apo-Transferrine human

powder, ≥98% (agarose gel electrophoresis)

• Synonyme(s) : Sidérophiline, Transferrine humaine
• Numéro CAS: 11096-37-0
• UNSPSC Code: 12352202
• EC Number: 234-318-8
• NACRES: NA.75
• MDL number: MFCD00130536
• eCl@ss: 34058011
• Form: powder
• Assay: ≥98% (agarose gel electrophoresis)
• Biological source: human
• Mol wt: 76-81 kDa

Propriétés

• biological source: human
• Quality Segment: 200
• assay: ≥98% (agarose gel electrophoresis)
• form: powder
• mol wt: 76-81 kDa
• Iron content: ≤0.005%
• technique(s): cell culture | mammalian: suitable
• impurities: HIV and HBsAg, source material tested negative
• solubility: H₂O: 50 mg/mL
• UniProt accession no.: P02787
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... TF(7018)

Description

General description

Apo-transferrin human is a glycoprotein, possessing homologous carboxyl and amino domain. Both the domain binds to one molecule of iron. Only 30% of transferrin is saturated with iron in the amino domain. Apo-transferrin in human is encoded by the gene TF which is localized on human chromosome 3q22.1.

Application

Apo-Transferrin human has been used:

• to determine the competitive binding of bismuth to albumin and transferrin by fast performance liquid chromatography (FPLC)
• to study titanium-transferrin complex by electrochemical method
• in the preparation of transferrin solution and in the formation of conjugates with ruthenium-complexes for cellular viability studies

Biochem/physiol Actions

Apo-transferrin is an iron transport protein. The concentration of transferrin in blood plasma is about 35 μM. Transferrin also functions in the transport of therapeutic, diagnostic and toxic ions like Ga³⁺, Ru³⁺ and Al³⁺. Polymorphism in TF gene has pathological implications in Parkinson′s disease.

Apo-transferrin is required for the survival and differentiation of oligodendroglial cells.

Other Notes

Protéine de transport du fer du type non-hème.

Similar to T 2252

Disclaimer

Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3