T4182

Tyrphostin AG 1478

≥98%

• Synonyme(s) : N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
• Formule empirique (notation de Hill): C₁₆H₁₄ClN₃O₂
• Numéro CAS: 175178-82-2
• Poids moléculaire : 315.75
• Numéro MDL: MFCD00270914
• Code UNSPSC : 51111800
• ID de substance PubChem : 24278735
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98%
• Forme: solid
• Solubilité: 0.1 M HCl: soluble <0.4 mg/mL; DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless; ethanol: soluble 10 mg/mL; methylene chloride: soluble 10 mg/mL; 0.1 M NaOH: insoluble; 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
• InChI: 1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
• Clé InChI: GFNNBHLJANVSQV-UHFFFAOYSA-N
• Informations sur le gène: human ... EGFR(1956) ; mouse ... Egfr(13649)

Description

Application

Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.

Actions biochimiques/physiologiques

Tyrphostin AG 1478 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It contributes to the development of hypomagnesemia and cardiac dysfunction in rats. Tyrphostin AG 1478 acts as a potential therapeutic agent for breast cancer.

Selective inhibitor of epidermal growth factor receptor protein

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

Tyrphostin AG 1478 dissolves in DMSO:MeOH (1:1) at 10 mg/ml to yield a clear, colorless solution. It is also soluble in methylene chloride (10 mg/ml), ethanol (10 mg/ml) and 0.1 N HCl (less than 0.4 mg/ml). However, it is insoluble in water, 2-hydroxypropyl-β-cyclodextrin, and 0.1 N NaOH.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)