T2501

L-Thyroxine sodium salt pentahydrate

synthetic (organic), ≥98% (HPLC), Thyroid hormone, powder

• Synonyme(s) : 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, Sodium levothyroxine, T₄
• Formule linéaire : HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COONa · 5H₂O
• Numéro CAS: 6106-07-6
• Poids moléculaire : 888.93
• NACRES: NA.32
• PubChem Substance ID: 24900041
• UNSPSC Code: 51111800
• EC Number: 200-221-4
• MDL number: MFCD00149110
• Beilstein/REAXYS Number: 5721845
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥98% (HPLC)

Propriétés

• Nom du produit: L-Thyroxine sodium salt pentahydrate, ≥98% (HPLC), powder
• biological source: synthetic (organic)
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥98% (HPLC)
• form: powder
• mp: 207-210 (dec.) (lit.)
• solubility: 4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, colorless to yellow
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1
• InChI key: JMHCCAYJTTWMCX-QWPJCUCISA-M
• Gene Information: mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

Description

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Preparation Note

L-Thyroxine sodium salt pentahydrate dissolves in 4 N NH4OH in methanol at 50 mg/ml to yield a clear to hazy, colorless to yellow solution.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Danger
• hcodes: H372
• pcodes: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• target_organs: Thyroid,Cardio-vascular system,Kidney
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)