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T104

Sigma-Aldrich

Tropisetron

solid, ≥98% (HPLC)

Synonyme(s) :

ICS-205,930, Navoban, endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-ol Indol-3-yl-carboxylate hydrochloride

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About This Item

Formule empirique (notation de Hill):
C17H20N2O2 · HCl
Numéro CAS:
105826-92-4
Poids moléculaire :
320.81
Numéro MDL:
MFCD00210221
Code UNSPSC :
12352200
ID de substance PubChem :
24278133
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Solubilité

H2O: >10 mg/mL

Auteur

Novartis

Température de stockage

2-8°C

Chaîne SMILES 

Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34

InChI

1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H

Clé InChI

XIEGSJAEZIGKSA-UHFFFAOYSA-N

Informations sur le gène

human ... CHRNA3(1136) , CHRNA4(1137) , CHRNB2(1141) , CHRNB4(1143) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)
rat ... Chrna7(25302) , Drd2(24318) , Htr1a(24473) , Htr3a(79246)

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Application

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

Actions biochimiques/physiologiques

Tropisetron a selective serotonin 5-HT3 receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.
3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT3 serotonin receptor antagonist.

Caractéristiques et avantages

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

N Yoshida et al.
The Journal of pharmacology and experimental therapeutics, 256(1), 272-278 (1991-01-01)
We studied the effect of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists on gastrointestinal (GI) motor activity in conscious dogs with force transducers implanted chronically. During the digestive state, GR38032F, BRL 43694 and ICS 205-930 did not affect GI motor activity at
Q Pei et al.
European journal of pharmacology, 230(1), 63-68 (1993-01-05)
The effects of three different 5HT3 receptor antagonists, granisetron, ICS 205-930 and ondansetron (0.01, 0.1 and 1 mg/kg, s.c.) were tested on changes in mesolimbic dopamine function produced by 1 mg/kg of morphine in the rat. Increases of in vivo
Li Yu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 846(1-2), 20-23 (2006-09-12)
A simple and sensitive high performance liquid chromatography method with UV detection was described for the determination of tropisetron in human plasma. The prepared sample solution was injected onto BDS-C(8) reversed column using a mixture of ammonium acetate (100 mM
E Beubler et al.
European journal of pharmacology, 248(2), 157-162 (1993-08-02)
The effects of cholera toxin and heat stable Escherichia coli (E. coli) enterotoxin on intestinal fluid secretion are commonly considered to be mediated by cyclic nucleotides. It was demonstrated recently, by using the 5-hydroxytryptamine (5-HT)2 receptor antagonist ketanserin and the
Orie Tomoyose et al.
Journal of pharmacological sciences, 126(2), 136-145 (2014-09-26)
Fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, has been shown to exert analgesic effects in humans and laboratory animals. However, its effects on spinal nociceptive synaptic transmission have not been fully characterized. Here, whole-cell recordings were made from dorsal horn
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