SRP3079
IL-16 human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonyme(s) :
LCF (Lymphocyte Chemoattractant Factor)
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Produit recombinant
expressed in E. coli
Pureté
≥98% (HPLC)
≥98% (SDS-PAGE)
Forme
lyophilized
Poids mol.
12.4 kDa
Conditionnement
pkg of 10 μg
Technique(s)
cell culture | mammalian: suitable
Impuretés
<0.1 EU/μg endotoxin, tested
Couleur
white to off-white
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
human ... IL16(3603)
Description générale
IL-16 (interleukin 16), or LCF (lymphocyte chemoattractant factor), was first functionally and biochemically characterized in 1982. IL-16 is produced as a precursor protein (pro-IL16), composed of 631 residues which undergoes cleavage by caspase-3 to produce and secrete a C-terminal biologically active peptide of 121 amino acids. This gene is localized to human chromosome 15q26.3.
Actions biochimiques/physiologiques
IL-16 (interleukin 16) is a pleiotropic proinflammatory cytokine that stimulates chemotactic and immunomodulatory responses of CD4+ (cluster of differentiation) lymphocytes, monocytes, and eosinophils, via signaling through CD4. It prevents HIV (human immunodeficiency virus) replication, and promotes the expression of IL-2R by human T-cells. Study in Chinese population show that polymorphisms in this gene are linked with susceptibility to knee osteoarthritis (OA). IL-16 plays a key role in the release of tumor-related inflammatory cytokines, and the rs4778889 variant in this gene is linked with increased risk of RCC (renal cell cancer) in Chinese population.
Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4kDa protein consisting of 121 amino acid residues.
Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4kDa protein consisting of 121 amino acid residues.
Séquence
SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S
Forme physique
Lyophilized from 5 mM Sodium Citrate, pH 5.5 + 0.5 mM DTT.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Eye Irrit. 2
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population.
Yang SX et al
Genetics and molecular research : GMR, 15(2) (2016)
Conservation of structure and function between human and murine IL-16.
Keane J et al
Journal of Immunology, 160(12), 5945-5954 (1998)
Center, D.M., et al.
Cytokine Reference, 226-240 (2001)
Shi-Xing Luo et al.
PloS one, 10(5), e0123442-e0123442 (2015-05-09)
Interleukin-16 (IL-16), a pleiotropic cytokine, plays a fundamental role in inflammatory diseases. This study investigates the association between IL-16 polymorphisms and the risk of knee osteoarthritis (OA) in a Chinese population. The IL-16 rs11556218, rs4072111, and rs4778889 polymorphisms were determined
W W Cruikshank et al.
Journal of immunology (Baltimore, Md. : 1950), 157(12), 5240-5248 (1996-12-15)
We have recently described the cDNA and predicted protein structure of a natural soluble CD4 ligand, IL-16. IL-16 is chemotactic for CD4+ T cells and induces functional IL-2 receptors in CD4+ T cells. The binding of IL-16 to CD4 results
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