SML3388

Vortioxetine hydrobromide

≥98% (HPLC), 5-HT-1D/3A/7 antagonist, powder

• Synonyme(s) : 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine hydrobromide, Lu AA21004 HBr, Lu AA21004 hydrobromide, Vortioxetine HBr
• Formule empirique (notation de Hill) : C₁₈H₂₂N₂S·HBr
• Numéro CAS: 960203-27-4
• Poids moléculaire : 379.36
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD22383961
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propriétés

• Nom du produit: Vortioxetine hydrobromide, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S(c2c(cccc2)N3CC[N+H2]CC3)c1c(cc(cc1)C)C.[Br-]
• InChI: 1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
• InChI key: VNGRUFUIHGGOOM-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Orally active, multimodal serotonergic compound with in vivo psychotropic efficacy by targeting 5-HT-1A/1B/1D/3A/7 and SERT.

Vortioxetine (Lu AA21004) is an orally active, multimodal serotonergic compound with high affinity toward human 5-HT1A (Ki = 15 nM), 5-HT1B (Ki = 33 nM), 5-HT1D (Ki = 54 nM), 5-HT3A (Ki = 3.7 nM), 5-HT7 (Ki = 19 nM), noradrenergic β1 (Ki = 46 nM) receptors, and serotonin (5-HT) transporter (SERT Ki = 1.6 nM). Vortioxetine exhibits in vivo psychotropic efficacy by exerting antagonist activity against 5-HT-1D/3A/7, agonist activity on 5-HT1A, partial agonist activity on 5-HT1B, as well as potent SERT inhibitory activity.

Informations sur la sécurité

• pictograms: GHS08,GHS09
• signalword: Warning
• hcodes: H361d,H373,H410
• pcodes: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2
• target_organs: Kidney
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable