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SML2370

Dabigatran

Name: Dabigatran
Brand: SIGMA

≥95% (HPLC), Nonpeptide direct thrombin inhibitor, powder

Synonyme(s) :

BIBR-953, N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₅H₂₅N₇O₃

Numéro CAS:

211914-51-1

Poids moléculaire :

471.51

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD09837830

Assay:

≥95% (HPLC)

Form:

powder

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Propriétés

Nom du produit

Dabigatran, ≥95% (HPLC)

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

0.1 M HCl: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N=C(N)C(C=C1)=CC=C1NCC(N2C)=NC3=C2C=CC(C(N(CCC(O)=O)C4=NC=CC=C4)=O)=C3

InChI

1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)

InChI key

YBSJFWOBGCMAKL-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Dabigatran is a nonpeptide direct thrombin inhibitor. It is an anticoagulant that functions by directly inhibiting both free and fibrin-bound thrombin. Dabigatron has been shown to prevent strokes in those with atrial fibrillation not caused by heart valve issues.

Nonpeptide, direct thrombin inhibitor

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Cet article	SML2351	SML0853	SML2094
Sigma-Aldrich SML2370 Dabigatran	Sigma-Aldrich SML2351 Dabigatran etexilate	Sigma-Aldrich SML0853 SB 699551 dihydrochloride	Sigma-Aldrich SML2094 BIBO 3304 trifluoroacetate salt
description ≥95% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC)
form powder	form powder	form powder	form powder
assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility 0.1 M HCl: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility H₂O: 1 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear
color white to beige	color white to beige	color white to beige	color white to beige

Classe de stockage

11 - Combustible Solids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Questions

Anonymous

3 years ago

Hello, How to reconstitute dabigatran? Thank you

1 answer
1. Technical Support
  
  3 years ago
  
  This product can be solubilized in 0.1M HCl at > 2.0 mg/ml. The exact solubility of this product will be listed on the lot-specific Certificate of Analysis.
  Please navigate to the DOCUMENTATION section of the Product Detail Page to access a sample or lot specific Certificate under ‘Certificate of Analysis’:
  https://www.sigmaaldrich.com/product/sigma/sml2370#product-documentation
  
  Helpful?

Reviews

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X. Tian
X. Tian

Geneva
Review 1

Votes 0
1 out of 5 stars.

X. Tian

2 years ago

Too large bootle for 5 mg bottle
Placing a 5 mg powder in a large glass bottle is really inconvenient. The power cannot be taken out at all.

A donation to charity was made for this review

No

Recommends this product

No
Helpful?
1. Response from Merck KGaA:
  
  Anonymous Technical Support
  2 years ago
  
  Thank you for your review.
  SML2370 is supplied in a large enough vial for the product to be reconstituted in it. This allows the full amount to be reconstituted without losing powder while transferring. Please do not transfer powder out of the vial before reconstitution.
  We encourage customers who experience problems with our products to contact us for additional technical support. Please visit https://www.sigmaaldrich.com/US/en/support/customer-support to submit a Product Technical Inquiry.