SML2272

AZD-2098

≥98% (HPLC)

• Synonyme(s) : 2,3-Dichloro-N-(3-methoxy-2-pyrazinyl)benzenesulfonamide, 2,3-Dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide, AZD 2098, AZD2098
• Formule empirique (notation de Hill) : C₁₁H₉Cl₂N₃O₃S
• Numéro CAS: 566203-88-1
• Poids moléculaire : 334.18
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD31382158
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=S(C1=CC=CC(Cl)=C1Cl)(NC2=NC=CN=C2OC)=O
• InChI key: FLSMVCMSUNISFK-UHFFFAOYSA-N

Description

Biochem/physiol Actions

AZD-2098 is an orally active, potent and selective CCR4 antagonist (pIC50 = 7.8/8.0/8.0/7.6 against CCL22 binding to human/mouse/rat/dog CCR4; inactive toward CXCR1/2 & CCR1/2b/5/7/8 at 10 μM) with little or no activity toward a panel of ∼120 receptors/enzymes. AZD-2098 effectively inhibits chemokine-induced cellular responses in vitro (pIC50 = 7.5 against CCL22-induced calcium influx in hCCR4-expressing CHO cells; pIC50 = 6.3 against CCL17- or CCL22-induced chemotaxis of primary human Th2 cells) and exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats in vivo (Emax = 7.5 μmol/kg p.o.; 1 h before and every 12 h after antigen challenge).

Orally active, potent and selective CCR4 antagonist with efficacy against antigen-induced inflammatory response in ovalbumin-sensitized rats in vivo.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable