SML2109

ST034307

≥98% (HPLC)

• Synonyme(s) : 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one, 6-Chloro-2-(trichloromethyl)chromen-4-one
• Formule empirique (notation de Hill) : C₁₀H₄Cl₄O₂
• Numéro CAS: 133406-29-8
• Poids moléculaire : 297.95
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00760793
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• assay: ≥98% (HPLC)
• form: powder
• color: faint green to dark gray
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: −20°C
• SMILES string: ClC(Cl)(Cl)C1=CC(C2=CC(Cl)=CC=C2O1)=O
• InChI: 1S/C10H4Cl4O2/c11-5-1-2-8-6(3-5)7(15)4-9(16-8)10(12,13)14/h1-4H
• InChI key: NTDHYMSVCBGQJF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity. Adenylyl cyclase 1 has been shown to be a potential target for treating pain and reducing the dependency on opioids, but it has been difficult to inhibit AC1 selectively without also inhibiting other isoforms vital to physiological functions. ST034307 is selective for AC1 over all eight other adenylyl cyclase isoforms. It inhibited AC1 and reduced cAMP, while leaving AC8 unaffected and was shown to reduce pain in a mouse inflammatory pain model.

Selective inhibitor of adenylyl cyclase 1 (AC1) with analgesic activity

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3