SML1767

Sparstolonin B

≥98% (HPLC)

• Synonyme(s) : 4,10-Dihydroxy-3H-pyrano[3,4,5-kl]xanthen-3-one, Sparstolenin B, SsnB
• Formule empirique (notation de Hill) : C₁₅H₈O₅
• Numéro CAS: 1259330-61-4
• Poids moléculaire : 268.22
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3
• InChI: 1S/C15H8O5/c16-7-1-3-11-8(5-7)9-6-19-15(18)14-10(17)2-4-12(20-11)13(9)14/h1-6,16-17H
• InChI key: DHSASSJDMAHICE-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties

Sparstolonin B (SsnB), an isocoumarin isolated from Sparganium stoloniferum and Scirpus yagara, is a potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties. Sparstolonin B inhibits LPS induced inflammation in 3T3- L1 adipocytes, and reduces the body weight of rats fed with high fat diet. Sparstolonin B mitigates inflammation in nonalcoholic steatohepatitis (NASH) in mice model.

Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H315,H319
• Mentions de précaution: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable