SML1558
Yoda1
≥98% (HPLC), powder, Piezo1 agonist
Synonyme(s) :
2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Formule empirique (notation de Hill):
C13H8Cl2N4S2
Numéro CAS:
Poids moléculaire :
355.27
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
Produits recommandés
product name
Yoda1, ≥98% (HPLC)
Niveau de qualité
Pureté
≥98% (HPLC)
Forme
powder
Couleur
white to beige
Solubilité
DMSO: 15 mg/mL, clear
Température de stockage
2-8°C
Description générale
Yoda1 is a novel synthetic small molecule developed to study the kinetics, regulation and function of the cation channel Piezo-type mechanosensitive ion channel component 1 (Piezo1).
Application
Yoda1 has been used to investigate its effect on heterotrimeric Piezo1 channels.
Actions biochimiques/physiologiques
Yoda1 is a specific activator of mouse and human cation channel Piezo1, a mechanosensitive channel that mediates Ca2+ influx on mechanical activation and has been linked to a role in blood vessel development. Yoda1 stabilizes the Piezo1 open channel. In red blood cells, this was followed by downstream activation of the KCa3.1 Gardos channel with resultant calcium influx and potassium and water efflux, causing shrinkage of the cells. Yoda1 is the first Piezo1 agonist, giving the first evidence of non-mechanical activation of a Piezo channel.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Les clients ont également consulté
Lei Liu et al.
Frontiers in pharmacology, 12, 606245-606245 (2021-04-13)
XueShuanTong (XST) comprising therapeutically active ginsenosides, a lyophilized extract of Panax notoginseng roots, is extensively used in traditional Chinese medicine to treat ischemic heart and cerebrovascular diseases. Our recent study shows that treatment with XST inhibits shear-induced thrombosis formation but
Jerome J Lacroix et al.
Nature communications, 9(1), 2029-2029 (2018-05-26)
Piezo proteins are transmembrane ion channels which transduce many forms of mechanical stimuli into electrochemical signals. Their pore, formed by the assembly of three identical subunits, opens by an unknown mechanism. Here, to probe this mechanism, we investigate the interaction
Immacolata Andolfo et al.
American journal of hematology, 95(2), 188-197 (2019-11-19)
Dehydrated hereditary stomatocytosis (DHS), or xerocytosis, is an autosomal dominant hemolytic anemia. Most patients with DHS carry mutations in the PIEZO1 gene encoding a mechanosensitive cation channel. We here demonstrate that patients with DHS have low levels of hepcidin and
Chemical gating of the mechanosensitive Piezo1 channel by asymmetric binding of its agonist Yoda1.
Lacroix JJ, et al.
bioRxiv, 169516-169516 (2017)
Erika Sugisawa et al.
Cell, 182(3), 609-624 (2020-07-09)
Gastrointestinal enterochromaffin cells regulate bone and gut homeostasis via serotonin (5-hydroxytryptamine [5-HT]) production. A recent report suggested that gut microbes regulate 5-HT levels; however, the precise underlying molecular mechanisms are unexplored. Here, we reveal that the cation channel Piezo1 in
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique