SML1236

(−)-Nicotine hydrogen tartrate salt

≥98% (HPLC), acetylcholine receptor agonist, powder

• Synonyme(s) : (−)-Nicotine ditartrate, (−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt
• Formule empirique (notation de Hill) : C₁₀H₁₄N₂ · 2C₄H₆O₆
• Numéro CAS: 65-31-6
• Poids moléculaire : 462.41
• UNSPSC Code: 12352210
• PubChem Substance ID: 329825736
• NACRES: NA.77
• EC Number: 200-607-2
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propriétés

• Nom du produit: (−)-Nicotine hydrogen tartrate salt, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +20 to +26°, c = 1.0 in water
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: CN1CCC[C@H]1C2=CC=CN=C2.C
• InChI: 1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1
• InChI key: RYYKFQGHMYGLEL-PPHPATTJSA-N

Description

Application

(−)-Nicotine hydrogen tartrate salt has been used in intracellular calcium imaging.

(−)-Nicotine hydrogen tartrate salt has been used as an agonist for acetylcholine receptor (AChr).

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

NHT is considered to be more stable than nicotine. Nicotine is highly addictive drug and is indirectly but strongly associated with tobacco related diseases. It helps to discontinue smoking. Nicotine might serve as a therapeutic agent in treating Alzheimer’s disease, Parkinson’s disease and ulcerative colitis.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08,GHS09
• Mot-clé: Danger
• Codes de danger: H301,H319,H330,H361d,H411
• Mentions de précaution: P202 - P260 - P264 - P273 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Que se passe-t-il ?: WGK 2
• Point d'éclair (°F): 289.8 °F
• Point d'éclair (°C): 143.2 °C