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SML0737

MitoTEMPO

Name: MitoTEMPO
Brand: SIGMA

≥98% (HPLC), powder, antioxidant

Synonyme(s) :

(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride, Mito-TEMPO

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₉H₃₅N₂O₂P · Cl

Numéro CAS:

1334850-99-5

Poids moléculaire :

510.03

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated, protect from light

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Propriétés

Nom du produit

MitoTEMPO, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to light brown

solubility

H₂O: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

[P+](CC(=O)NC4CC(N(C(C4)(C)C)[O])(C)C)(c3ccccc3)(c2ccccc2)c1ccccc1.[Cl-]

InChI

1S/C29H34N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23H,20-22H2,1-4H3;1H

InChI key

WKKFJIJNGHNQQW-UHFFFAOYSA-N

Description

Application

MitoTEMPO has been used as a mitochondria-targeted antioxidant.

Biochem/physiol Actions

MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide.

MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide. MitoTEMPO is a combination of the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, giving MitoTEMPO the ability to pass through lipid bilayers with ease and accumulate several hundred-fold in mitochondria. Mitochondrial dysfunction and oxidative stress contribute to a variety of disorders involving cardiovascular, kidney, liver disorders, Parkinson′s and Alzheimer′s disease.

Other Notes

Light sensitive

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Cet article	581500	SML0882	SML2431
Sigma-Aldrich SML0737 MitoTEMPO	Sigma-Aldrich 581500 TEMPOL	Sigma-Aldrich SML0882 Aurora-A Inhibitor I	Sigma-Aldrich SML2431 VU0134992 hydrochloride
description ≥98% (HPLC)	description A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap.	description ≥98% (HPLC)	description ≥98% (HPLC)
assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form crystals, powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: 10 mg/mL, clear	solubility DMSO: 5 mg/mL, ethanol: soluble, water: soluble	solubility DMSO: 10 mg/mL, clear	solubility DMSO: 2 mg/mL, clear
storage condition desiccated, protect from light	storage condition OK to freeze, protect from light	storage condition -	storage condition desiccated

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number

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