Unfortunately, the stability of the solution for this product has not been determined.
SML0569
RO-3306
≥98% (HPLC), powder, CDK1 inhibitor
Synonyme(s) :
(5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one, 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
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A propos de cet article
Formule empirique (notation de Hill) :
C18H13N3OS2
Numéro CAS:
Poids moléculaire :
351.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Le tarif et la disponibilité ne sont pas disponibles actuellement.
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Laissez-nous vous aiderNom du produit
RO-3306, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
off-white to brown
solubility
DMSO: 5 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC4=C(C=C3)N=CC=C4
InChI
1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChI key
XOLMRFUGOINFDQ-YBEGLDIGSA-N
Application
RO-3306 has been used:
- To study the significance of CA4-mediated cytotoxicity in mitotic arrest
- In cell cycle synchronization to conduct a study on proteomics
- As a CDK1 inhibitor, to prevent early mitotic entry
Biochem/physiol Actions
RO-3306 is a selective ATP-competitive inhibitor of CDK1.
RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.
CDK1 (cyclin dependent kinase 1) is considered to be the “master switch” in cell division, which maintains the mitotic state of cells.
Features and Benefits
This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Cet article | |||
|---|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 5 mg/mL, clear | solubility DMSO: 20 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 20 mg/mL, clear |
| color off-white to brown | color yellow to orange | color white to beige | color white to beige |
Classe de stockage
11 - Combustible Solids
Que se passe-t-il ?
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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After dissolving the product, can i freeze my aliquots? If i can't freeze them, then how long is it viable at 4 degrees
1 answer-
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