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SML0327

AM630

Name: AM630
Brand: SIGMA

≥90% (HPLC), CP 55,940 antagonist, powder

Synonyme(s) :

6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone, AM 630, Iodopravadoline

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A propos de cet article

Formule empirique (notation de Hill) :

C₂₃H₂₅IN₂O₃

Numéro CAS:

164178-33-0

Poids moléculaire :

504.36

UNSPSC Code:

12352200

PubChem Substance ID:

329825332

NACRES:

NA.77

MDL number:

MFCD01861183

Assay:

≥90% (HPLC)

Form:

powder

Storage condition:

desiccated

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Propriétés

Nom du produit

AM630, ≥90% (HPLC)

Quality Segment

100

assay

≥90% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C(=O)c2c(C)n(CCN3CCOCC3)c4cc(I)ccc24

InChI

1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3

InChI key

JHOTYHDSLIUKCJ-UHFFFAOYSA-N

Description

Application

AM630 has been used:

as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from Trametes versicolor (TPSP).
as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells.
as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts.

Biochem/physiol Actions

AM630 is a selective CB2 cannabinoid antagonist/inverse agonist (Ki = 31.2 nM) with > 150-fold selectivity over CB1 receptors.

AM630 is a selective CB2 cannabinoid antagonist/inverse agonist.

AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogrammes

GHS09

Mot-clé

Warning

Codes de danger

H410

Mentions de précaution

P273 - P391 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Classe de stockage

11 - Combustible Solids

Que se passe-t-il ?

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)