SML0180

Aceclidine hydrochloride

≥98% (HPLC)

• Synonyme(s) : 1-Azabicyclo[2.2.2]oct-3-yl acetate hydrochloride, 3-Acetoxyquinuclidine hydrochloride
• Formule empirique (notation de Hill) : C₉H₁₅NO₂ · HCl
• Numéro CAS: 6109-70-2
• Poids moléculaire : 205.68
• PubChem Substance ID: 329825209
• UNSPSC Code: 12352200
• NACRES: NA.77
• EC Number: 228-071-5
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propriétés

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: H₂O: ≥15 mg/mL at ~60 °C
• storage temp.: −20°C
• SMILES string: Cl.CC(=O)O[C@H]1CN2CC[C@H]1CC2
• InChI: 1S/C9H15NO2.ClH/c1-7(11)12-9-6-10-4-2-8(9)3-5-10;/h8-9H,2-6H2,1H3;1H/t9-;/m0./s1
• InChI key: LWWSARSTZGNKGV-FVGYRXGTSA-N

Description

Application

Aceclidine hydrochloride may be used in muscarinic acetylcholine receptor-mediated cell signaling studies.

Biochem/physiol Actions

Aceclidine hydrochloride is a parasympathomimetic drug with weak anticholinesterase activity. It acts on cholinergic nerve-endings, lowers intraocular pressure and potent therapeutic agent for open-angle glaucoma.[1]

Aceclidine is a non-selective muscarinic acetylcholine receptor partial agonist that is effective in reducing intraocular pressure.

Muscarinic receptor partial agonist

Aceclidine at a concentration of 5 and 50 μg is capable of enhancing the outflow facility, following ciliary muscle disinsertion.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311
• pcodes: P264 - P280 - P301 + P310 - P302 + P352 + P312 - P361 + P364 - P405
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable