SML0142

Valsartan

≥98% (HPLC)

• Synonyme(s) : N-(1-Oxopentyl)-N-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-L-valine
• Formule empirique (notation de Hill): C₂₄H₂₉N₅O₃
• Numéro CAS: 137862-53-4
• Poids moléculaire : 435.52
• Numéro MDL: MFCD00865840
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825190
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D -55 to -70°, c = 1 in methanol
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: DMSO: ≥20 mg/mL
• Auteur: Novartis
• Température de stockage: 2-8°C
• Chaîne SMILES: CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
• InChI: 1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
• Clé InChI: ACWBQPMHZXGDFX-QFIPXVFZSA-N
• Informations sur le gène: human ... AGTR1(185)

Description

Application

Mice were treated with valsartan to study the role of Ang II-dependent pathway in aldosterone-related effects.

Actions biochimiques/physiologiques

Valsartan is an Angiotensin II type 1 (AT1) receptor antagonist and anti-hypertensive. Valsartan renders protection against heart attack and stroke resulting from abrupt increase in blood pressure. Valsartan reduces myocardial-infarction-related complications in heart attack survivors.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H336,H361d
• Conseils de prudence: P201 - P308 + P313
• Classification des risques: Repr. 2 - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable