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SML0034

Sigma-Aldrich

1-EBIO

≥98% (HPLC)

Synonyme(s) :

1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one; 1-Ethylbenzimidazolinone

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About This Item

Formule empirique (notation de Hill) :
C9H10N2O
Numéro CAS:
10045-45-1
Poids moléculaire :
162.19
Numéro CE :
233-148-1
Numéro MDL:
MFCD00005715
Code UNSPSC :
12352200
ID de substance PubChem :
329825104
Nomenclature NACRES :
NA.77

Essai

≥98% (HPLC)

Forme

powder

Solubilité

DMSO: ≥20 mg/mL

Température de stockage

room temp

Chaîne SMILES 

CCN1C(=O)Nc2ccccc12

InChI

1S/C9H10N2O/c1-2-11-8-6-4-3-5-7(8)10-9(11)12/h3-6H,2H2,1H3,(H,10,12)

Clé InChI

CXUCKELNYMZTRT-UHFFFAOYSA-N

Application

1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.

Actions biochimiques/physiologiques

1-EBIO is an activator of epithelial Ca2+-activated K+ channel also known as the intermediate-conductance Ca(2+)-activated K(+) channel (IK-1) or KCa3.1.
1-EBIO is an activator of epithelial Ca2+-activated K+ channel
1-EBIO potentiates the secretion of CFTR-mediated Cl− ion secretion by activating the basolateral KCNN4 K+ channels in native human colonic tissues. It stimulates the apical Cl− channels and Ca+2-dependent basolateral K+ channels to stimulate fluid transport in lacrimal glands.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
0000157676
0000157676
0000157009
0000156239
0000156239

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Lawrence J Alvarez et al.
American journal of physiology. Cell physiology, 289(1), C138-C147 (2005-02-11)
Experiments were conducted to determine whether the Cl- secretagogue, 1-ethyl-2-benzimidazolinone (EBIO), stimulates Cl- transport in the rabbit conjunctival epithelium. For this study, epithelia were isolated in an Ussing-type chamber under short-circuit conditions. The effects of EBIO on the short-circuit current
P Pedarzani et al.
The Journal of biological chemistry, 276(13), 9762-9769 (2001-01-13)
In most central neurons, action potentials are followed by an afterhyperpolarization (AHP) that controls firing pattern and excitability. The medium and slow components of the AHP have been ascribed to the activation of small conductance Ca(2+)-activated potassium (SK) channels. Cloned
Dorte Strøbaek et al.
Biochimica et biophysica acta, 1665(1-2), 1-5 (2004-10-09)
We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels of SK and IK types, whereas it is devoid of effect on BK type channels. IK- and SK-channels have previously
Young-Woo Nam et al.
Scientific reports, 7(1), 17178-17178 (2017-12-08)
Small-conductance Ca
Patrick J Mulholland et al.
Biological psychiatry, 69(7), 625-632 (2010-11-09)
Small conductance calcium-activated potassium type 2 channels (SK2) control excitability and contribute to plasticity by reducing excitatory postsynaptic potentials. Recent evidence suggests that SK2 channels form a calcium-dependent negative-feedback loop with synaptic N-methyl-D-aspartate (NMDA) receptors. Addiction to alcohol and other
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Potassium Channels

We offer many products related to potassium channels for your research needs.

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