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SMB00424

Sigma-Aldrich

Platycodin D

≥98% (HPLC)

Synonyme(s) :

3β-(β-D-glucopyranosyloxy)-2β,16α,23,24-tetrahydroxy-O-D-apio-β-D-furanosyl-(1→3)-O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-olean-12-en-28-oic acid

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About This Item

Formule empirique (notation de Hill):
C57H92O28
Numéro CAS:
58479-68-8
Poids moléculaire :
1225.32
Code UNSPSC :
12352205
ID de substance PubChem :
329825010
Nomenclature NACRES :
NA.25

Niveau de qualité

200

Pureté

≥98% (HPLC)

Forme

powder

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Température de stockage

2-8°C

Chaîne SMILES 

O[C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(CO)(CO)[C@]3([H])CC[C@@]4(C)[C@]5(C)C[C@@H](O)[C@@]6(C(O[C@H]7[C@H](O[C@@H]8O[C@@H](C)[C@H](O[C@H]9[C@H](O)[C@@H](O[C@@H]%10OC[C@@](CO)(O)[C@H]%10O)[C@H](O)CO9)[C@@H](O)[C@H]8O)[C@@H](O)[C@@H](O

InChI

1S/C57H92O28/c1-23-40(81-45-39(72)41(30(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)29(63)17-77-48(42)85-50(74)57-12-11-51(2,3)14-27(57)24-7-9-52(4)26-13-28(62)44(84-47-37(70)35(68)34(67)31(16-58)80-47)55(19-59,20-60)25(26)8-10-54(52,6)53(24,5)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25+,26-,27-,28-,29-,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48?,49-,52+,53+,54+,56+,57+/m0/s1

Clé InChI

RJDYKSRQTBCKLC-XTIQGCOGSA-N

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Description générale

Platycodin D (PD) is a triterpenoid saponin found in the root of Platycodon grandifloras called Platycodonis Radix.

Application

Platycodin D has been used:
  • to test its anti-inflammatory and inhibitory effect on eosinophilic airway inflammation and T-helper type 2 (Th2) signaling pathways using ovalbumin (OVA)-induced allergic asthma mouse model
  • to test its anti-obese effects on the activation of brown adipose tissue featuring in vivo and in vitro studies
  • to test its efficacy as an adjuvant with infectious bronchitis (IB) vaccine in chicken

Actions biochimiques/physiologiques

Platycodin D elicits strong anti-cancer properties and exhibits cytotoxicity against several cancer cell lines of both in vitro and in vivo origin. It exerts anti-inflammatory and protective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by upregulating liver-X receptors α (LXRα) and ATP-binding cassette transporter A1 (ABCA1) signaling pathway. It also possesses protective effects against Cisplatin (CDDP)-induced nephrotoxicity in mice.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Tae-Won Kim et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(12), 4254-4259 (2012-05-24)
Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR
Yefei Zhou et al.
The journal of poultry science, 57(2), 160-167 (2020-05-29)
Adjuvants are common vaccine components. Novel adjuvants may improve the protective immunity conferred by vaccines against poultry diseases. Here, a less-hemolytic saponin, platycodin D (PD), isolated from the root of Platycodon grandiflorum was investigated as a potential alternative adjuvant. PD
Yuan-Chuan Lin et al.
The American journal of Chinese medicine, 46(3), 537-549 (2018-03-30)
Platycodin D (PD) is the main active saponin isolated from Platycodon grandiflorum (PG) and is reported to exhibit anticancer, anti-angiogenic, anti-inflammation and anti-obesity biological effects. The current study aims to evaluate the therapeutic efficacy of PD in cardiac fibrosis and
Muhammad Khan et al.
Journal of cellular and molecular medicine, 20(3), 389-402 (2015-12-10)
Cancer is a multi-faceted disease comprised of a combination of genetic, epigenetic, metabolic and signalling aberrations which severely disrupt the normal homoeostasis of cell growth and death. Rational developments of highly selective drugs which specifically block only one of the
J L Gajewski et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 7(11), 1637-1645 (1989-11-01)
One hundred ninety-six patients with acute myelogenous leukemia (AML) were treated with intensive induction chemotherapy using similar daunorubicin/cytarabine/thioguanine regimens. Treatment results of 44 patients who had a documented preleukemic syndrome or cytopenia present for more than 2 months before developing
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