SCP0148
Furin Inhibitor II Peptide
≥95% (HPLC), lyophilized powder
Synonyme(s) :
Hexa-D-arginine amide
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About This Item
Formule empirique (notation de Hill) :
C36H75N25O6
Poids moléculaire :
954.14
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32
Produits recommandés
Nom du produit
Furin Inhibitor II,
Essai
≥95% (HPLC)
Forme
lyophilized
Composition
Peptide Content, ≥48%
Conditions de stockage
protect from light
Technique(s)
protein extraction: suitable
Température de stockage
−20°C
Amino Acid Sequence
Mpa-Mpa-Mpa-Mpa-Mpa-Mpa
Description générale
Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.
Application
Furin Inhibitor II has been used as a furin inhibitor:
- to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
- to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
- in furin cleavage assay.
Actions biochimiques/physiologiques
Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
Inhibition of Glypican-3 Cleavage Results in Reduced Cell Proliferation in a Liver Cancer Cell Line.
Emily J Schepers et al.
The Journal of surgical research, 282, 118-128 (2022-10-23)
Glypican-3 (GPC3) is a surface-bound proteoglycan overexpressed in pediatric liver cancer and utilized clinically as an immunohistochemical tumor marker. Furin is a proprotein convertase that is ubiquitously expressed and shown to modify GPC3 post-translationally. In experimental models of epithelial-based cancers
Polyarginines are potent furin inhibitors
Cameron A, et al.
The Journal of Biological Chemistry, 275(47), 36741-36749 (2000)
Jingwen Yin et al.
Cells, 9(1) (2020-01-16)
Glial cell line-derived neurotrophic factor (GDNF) is expressed at a high level in the human ovary and GDNF signaling is involved in the direct control of follicular activation and oocyte maturation. Transforming growth factor-β1 (TGF-β1) plays an important role in
C M Dubois et al.
The American journal of pathology, 158(1), 305-316 (2001-01-06)
Transforming growth factor (TGF)-beta1 plays an essential role in cell growth and differentiation. It is also considered as a gatekeeper of immune homeostasis with gene disruption leading to autoimmune and inflammatory diseases. TGF-beta1 is produced as an inactive precursor polypeptide
(Pro) renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro) renin receptor in renal epithelial cells
Fang H, et al.
American Journal of Physiology. Cell Physiology, 313(6), C632-C643 (2017)
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