SAB5200055

Monoclonal Anti-KCNB1 antibody produced in mouse

clone S4-11, 1 mg/mL, purified immunoglobulin

• Synonyme(s) : Anti-DRK1PC, Anti-Kcnb1, Anti-Kcr1-1, Anti-Kv2.1, Anti-Kv2.1, S4-11, Anti-Shab
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Conjugué: unconjugated
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: S4-11, monoclonal
• Forme: buffered aqueous glycerol solution
• Poids mol.: antigen predicted mol wt 105-125 kDa
• Espèces réactives: human, mouse, rat, monkey
• Concentration: 1 mg/mL
• Technique(s): immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotype: IgG1
• Numéro d'accès NCBI: NP_037318
• Numéro d'accès UniProt: Q14721
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: rat ... Kcnb1(25736)

Description

Description générale

The potassium voltage-gated channel subfamily B member 1 (KCNB1) gene is mapped to human chromosome 20q13.13. This gene codes for a α subunit of voltage-gated potassium Kv2.1 channel. The encoded protein contains 858 amino acids and six transmembrane segments (S1–S6). KCNB1 is mainly expressed in the central nervous system, but at high level in somatodendritic compartment of neocortical and pyramidal neurons.

Spécificité

Detects ~105-125 kDa. Recognizes the Shab related α-subunit Kv2.1.

Immunogène

Bacterially expressed GST Bacterially expressed GSTfusion protein corresponding toamino acids 509-853 of rat KV2.1, Accession Number NM_004975.

Actions biochimiques/physiologiques

Potassium voltage-gated channel subfamily B member 1 (KCNB1) plays a vital role in hippocampal neuron excitation homeostasis. The encoded protein is mainly implicated in the generation of the major delayed rectifier potassium current in pyramidal neurons. Mutation in the gene is associated with the development of left ventricular (LV) hypertrophy and early-onset infantile epilepsy in humans.

Caractéristiques et avantages

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Forme physique

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable