SAB4200224

Anti-phospho-TDP-43 (pSer⁴¹⁰) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-phospho-ALS10, Anti-phospho-TAR DNA binding protein 43, Anti-phospho-TARDBP, Anti-phospho-TARDP43
• NACRES: NA.41
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: WB
• Citations: 7

Propriétés

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~43 kDa
• species reactivity: mouse, human
• concentration: ~1.0 mg/mL
• technique(s): western blot: 1-2 μg/mL using HepG2 and NIH3T3 cell lysates
• UniProt accession no.: Q13148
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer410)
• Gene Information: human ... TARDBP(23435) ; mouse ... Tardbp(230908)

Description

General description

TDP-43 (TAR DNA binding protein) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs), that binds single stranded RNA. TDP-43 has been implicated in the transcription regulation of HIV. TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype FTLD-U and amyotrophic lateral sclerosis (ALS). TDP-43 is predominantly localized to the nucleus.

Immunogen

synthetic peptide containing phosphorylated Ser410 of human TDP-43, conjugated to KLH. The corresponding sequence is identical in mouse TDP-43.

Application

Anti-phospho-TDP-43 (pSer410) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Several pathogenic TDP-43 mutations have been identified in familial amyotrophic lateral sclerosis (ALS).

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Classe de stockage: 10 - Combustible liquids
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable