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SAB4200206

Sigma-Aldrich

Anti-TRIM2 antibody produced in rabbit

enhanced validation

~1.5 mg/mL

Synonyme(s) :

Anti-RING finger protein 86, Anti-RNF86, Anti-Tripartite motif-containing protein 2

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~85 kDa

Espèces réactives

human, rat

Validation améliorée

recombinant expression
Learn more about Antibody Enhanced Validation

Concentration

~1.5 mg/mL

Technique(s)

western blot: 1.5-3.0 μg/mL using rat spinal cord extracts (S1 fraction) and HEK-293T cell lysates over expressing human TRIM2.

Numéro d'accès UniProt

Q9C040

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TRIM2(23321)
mouse ... Trim2(80890)
rat ... Trim2(361970)

Description générale

Tripartite motif containing 2 (TRIM2) is an E3 ubiquitin ligase, encoded by the gene mapped to human chromosome 4q31.3. The encoded protein belongs to the TRIM– NCL-1, HT2A and Lin-41 (NHL) protein family. This 81kDa protein is characterized with an N-terminal really interesting new gene (RING) finger domain and a B-box domain, a middle coiled-coil domain and a C-terminal NHL domain.
Tripartite motif-containing protein 2 (TRIM2), also known as RNF86, Narf is highly expressed in the nervous system.

Application

Anti-TRIM2 antibody produced in rabbit has been used in western blot analysis.
Anti-TRIM2 antibody produced in rabbit in immunoblotting and western blotting.

Actions biochimiques/physiologiques

Tripartite motif containing 2 (TRIM2) ubiquitinates neurofilament light chain, B-cell lymphoma 2 (Bcl-2)-interacting mediator and motor protein myosin V. It has a role in polarization of neurons and outgrowth of axons. Loss of function of the protein has been linked to early-onset axonal neuropathy.
Tripartite motif-containing protein (TRIM) RING finger proteins play an important role in cancerogenesis and in defense against viral infection. Mutations in the RING finger protein Parkin is associated with Parkinson′s disease (PD), and translocation of the TRIM gene is linked to acute promyelocytic leukemia. TRIM2 plays an important role in regulating neurofilament (NF-L) metabolism.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

RING finger 1 mutations in Parkin produce altered localization of the protein
Cookson MR, et al.
Human Molecular Genetics, 12(22), 2957-2965 (2003)
TRIM2, a novel member of the antiviral family, limits New World arenavirus entry
Sarute N, et al.
PLoS Biology, 17(2), e3000137-e3000137 (2019)
Exome sequencing reveals homozygous TRIM2 mutation in a patient with early onset CMT and bilateral vocal cord paralysis.
Pehlivan D
Human Genetics, 34, 671-673 (2015)
Emil Ylikallio et al.
Human molecular genetics, 22(15), 2975-2983 (2013-04-09)
Inherited peripheral neuropathies are a heterogeneous group of disorders that can affect patients of all ages. Children with inherited neuropathy often develop severe disability, but the genetic causes of recessive early-onset axonal neuropathies are not fully known. We have taken
Deficiency of the E3 ubiquitin ligase TRIM2 in early-onset axonal neuropathy
Ylikallio E, et al.
Human Molecular Genetics, 22(15), 2975-2983 (2013)
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