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Key Documents

SAB3500757

Sigma-Aldrich

Anti-NKX2-1 antibody produced in rabbit

affinity isolated antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Poids mol.

41 kDa

Espèces réactives

human, rat, mouse

Concentration

1 mg/mL

Technique(s)

ELISA: suitable
western blot: suitable

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NKX2-1(7080)

Description générale

NK2 homeobox 1 (NKX2-1) is expressed in epithelial cells of the thyroid gland and lungs. The gene encoding NKX2-1 is localized on human chromosome 14q13.

Immunogène

Antibody was raised against a 16 amino acid peptide near the amino terminus of human NKX2-1.

Actions biochimiques/physiologiques

NK2 homeobox 1(NKX2-1) has a role in the development of thyroid glands, lungs and brain. It modulates gene expression during embryogenesis. NKX2-1 has been found to be expressed in adenocarcinoma and small cell lung cancer. This protein acts as an immunohistological marker to distinguish between primary lung carcinoma and non-pulmonary cancer.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3500757.

Forme physique

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Distinct expression of NK2 homeobox 1 (NKX2-1) and goblet cell hyperplasia in nasal polyps with different endotypes.
Du J, et al.
International Forum of Allergy & Rhinology, 7(7) (2017)
Lara López-González et al.
Brain structure & function, 228(2), 537-576 (2023-01-05)
The ventromedial hypothalamic nucleus (VMH) is one of the most distinctive hypothalamic tuberal structures, subject of numerous classic and modern functional studies. Commonly, the adult VMH has been divided in several portions, attending to differences in cell aggregation, cell type
Value of thyroid transcription factor (TTF)-1 for diagnosis and prognosis of patients with locally advanced or metastatic small cell lung cancer.
Misch D, et al.
Diagnostic Pathology, 10(1), 21-21 (2015)
Benign hereditary chorea related to NKX2. 1: expansion of the genotypic and phenotypic spectrum.
Peall K J, et al.
Developmental Medicine and Child Neurology, 56(7), 642-648 (2014)
Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas.
Klingen T A, et al.
Diagnostic Pathology, 8(1), 80-80 (2013)

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