S7900

Saponin from quillaja bark

Sapogenin content ≥10 %

• Numéro CAS: 8047-15-2
• UNSPSC Code: 12161902
• EC Number: 232-462-6
• NACRES: NA.32
• MDL number: MFCD00081981

Propriétés

• description: non-ionic
• Quality Segment: 200
• composition: Sapogenin content, ≥10%
• technique(s): HPLC: suitable, protein quantification: suitable
• sulfated ash: <20%
• SMILES string: O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C(=O)O)O[C@@H]3[C@@](C4[C@@](C5[C@]([C@@]6(C[C@H]([C@]7([C@H]([C@@H](C(CC7C6=CC5)(C)C)OC(=O)\C(=C/C)\C)OC(=O)C)CO)O)C)(CC4)C)(CC3)C
• InChI key: AXNVHPCVMSNXNP-ZELRDNAQSA-N

Description

General description

Saponins are natural steroidal glycoside (terpenes).

Application

Saponin from Quillaja bark has been used:

• to stain CD4⁺ and CD8⁺ T-cells
• to lyse trophozoite-infected red blood cells
• in immunohistochemical staining

Biochem/physiol Actions

Saponins are associated with many biological and pharmacological activities. It is known to stimulate immune response in mammals. Hence it is used as vaccine adjuvants. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects.

Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.

Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H319,H335
• pcodes: P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves