S0439

SUMO-1 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli (GST-tagged)

• Synonyme(s) : Sentrin-1
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD03458656

Propriétés

• recombinant: expressed in E. coli (GST-tagged)
• Quality Segment: 200
• assay: ≥95% (SDS-PAGE)
• mol wt: 38.5 kDa
• UniProt accession no.: P63165
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... SUMO1(7341)

Description

General description

Small ubiquitin-like modifier 1 (SUMO-1), a protein, is one of the 5 SUMO paralogs expressed in mammalian cells with a low but significant homology with ubiquitin. This SUMO-1-GST fusion protein is produced from a DNA sequence corresponding to human SUMO-1 fused to a glutathione S-transferase (GST)-tag and is expressed in E. coli cells.

Application

SUMO-1 human has been used in pre-absorption for negative immunostaining to confirm the specificity of the small ubiquitin like modifier 1 (SUMO-1) antibody.

Biochem/physiol Actions

Small ubiquitin-like modifier 1 (SUMO-1) plays a key role in modulating survival, migration, and signal transduction in some cell lines. It can prevent in vitro migration and invasion of RA fibroblast-like synoviocytes (FLSs). Higher expression of SUMO-1 may result in joint destruction in rheumatoid arthritis (RA).

Conjugated to a variety of proteins by UbcH9, including RanGAP1, IκBα, and PML without the requirement of an equivalent E3 ubiquitin ligase.

Physical form

Solution in 50 mM HEPES, pH 8.0, 150 mM NaCl and 1 mM DTT.

Informations sur la sécurité

• Classe de stockage: 10 - Combustible liquids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)