PZ0250

PF-04859989 hydrochloride

≥98% (HPLC)

• Synonyme(s) : (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one; L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride, PF-4859989 hydrochloride, PF04859989 hydrochloride
• Formule empirique (notation de Hill): C₉H₁₀N₂O₂ · HCl
• Numéro CAS: 177943-33-8
• Poids moléculaire : 214.65
• Numéro MDL: MFCD22419400
• Code UNSPSC : 51111800
• ID de substance PubChem : 329823792
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: H₂O: 20 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl
• InChI: 1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1
• Clé InChI: WZOBDOKCHIUXAY-FJXQXJEOSA-N

Description

Actions biochimiques/physiologiques

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC₅₀ values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable