P8013

Pargyline hydrochloride

synthetic, 98% (TLC), MAO-B inhibitor, powder or crystals

• Synonyme(s) : N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride
• Formule linéaire : C₆H₅CH₂N(CH₃)CH₂C≡CH·HCl
• Numéro CAS: 306-07-0
• Poids moléculaire : 195.69
• NACRES: NA.77
• PubChem Substance ID: 24278153
• UNSPSC Code: 12352200
• EC Number: 206-175-1
• MDL number: MFCD00012492
• Beilstein/REAXYS Number: 3699487
• Assay: 98% (TLC)
• Form: powder or crystals

Propriétés

• Nom du produit: Pargyline hydrochloride,
• biological source: synthetic
• Quality Segment: 200
• assay: 98% (TLC)
• form: powder or crystals
• mp: 160-163 °C (lit.)
• solubility: water: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: Cl[H].CN(CC#C)Cc1ccccc1
• InChI: 1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
• InChI key: BCXCABRDBBWWGY-UHFFFAOYSA-N
• Gene Information: human ... MAOA(4128), MAOB(4129)

Description

Application

Pargyline hydrochloride has been used:

• as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training
• to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats,
• to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum

Biochem/physiol Actions

Pargyline hydrochloride acts as a histone demethylase inhibitor. It has antihypertensive action.

Selective MAO-B inhibitor.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mot-clé: Danger
• Codes de danger: H301
• Mentions de précaution: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Faceshields, Gloves