P7791

Prazosin hydrochloride

≥99.0% (HPLC), powder, α1-adrenoceptor antagonist

• Synonyme(s) : 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride, Furazosin hydrochloride
• Formule empirique (notation de Hill) : C₁₉H₂₁N₅O₄ · HCl
• Numéro CAS: 19237-84-4
• Poids moléculaire : 419.86
• NACRES: NA.77
• PubChem Substance ID: 24277793
• UNSPSC Code: 12352200
• EC Number: 242-903-4
• MDL number: MFCD00058177
• Beilstein/REAXYS Number: 4303561
• Assay: ≥99.0% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Prazosin hydrochloride, ≥99.0% (HPLC)
• Quality Segment: 100
• assay: ≥99.0% (HPLC)
• form: powder
• solubility: H₂O: 0.5 mg/mL, methanol: 6 mg/mL, dilute aqueous acid: insoluble
• SMILES string: Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
• InChI: 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
• InChI key: WFXFYZULCQKPIP-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

General description

Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.

Application

Prazosin hydrochloride has been used:

• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
• as an α1-adrenoceptor blocker,administered intragastrically in rats
• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Biochem/physiol Actions

Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.

Features and Benefits

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the α1-Adrenoceptors, α2-Adrenoceptors and Melatonin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Disclaimer

Hygroscopic; light sensitive.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07
• Mot-clé: Warning
• Codes de danger: H336,H361fd,H373
• Mentions de précaution: P202 - P260 - P271 - P280 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Repr. 2 - STOT RE 2 - STOT SE 3
• Organes cibles: Central nervous system
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Gloves