P7556

Progesterone-Water Soluble

powder, BioReagent, suitable for cell culture

• Synonyme(s) : Progesterone: HBC complex, Progesterone: methyl-β-cyclodextrin complex
• NACRES: NA.77
• PubChem Substance ID: 57654558
• UNSPSC Code: 12352209
• MDL number: MFCD00003658
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥65% (HPLC)

Propriétés

• biological source: synthetic (organic)
• Quality Segment: 200
• product line: BioReagent
• assay: ≥65% (HPLC)
• form: powder
• concentration: ≥65% (HPLC)
• technique(s): cell culture | mammalian: suitable
• solubility: H₂O: 25 mg/mL, clear to slightly hazy
• shipped in: ambient
• storage temp.: room temp
• SMILES string: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O
• InChI: 1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
• InChI key: RJKFOVLPORLFTN-LEKSSAKUSA-N
• Gene Information: human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Ar(24208), Nr3c1(24413), Pgr(25154)

Description

General description

Progesterone is a steroid hormone secreted by the ovaries.

Application

This product is not recommended for use in binding assays.

Progesterone-Water Soluble has been used:

• for in vitro maturation of oocyte complexes
• as a σ1R antagonist to study its effect on sigma 1 receptor
• to study its effect on the differentiation of human multipotent mesenchymal stromal cells (hMSCs) in vitro

Biochem/physiol Actions

Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.

Packaging

Package size based on progesterone content

Other Notes

Contains approx. 70 mg progesterone per gram; balance methyl-β-cyclodextrin.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360FD,H362
• pcodes: P202 - P260 - P263 - P264 - P280 - P308 + P313
• Hazard Classifications: Carc. 2 - Lact. - Repr. 1A
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable