P6004

Prednisolone

≥99% (HPLC), powder, glucocorticoid

• Synonyme(s) : 1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione
• Formule empirique (notation de Hill) : C₂₁H₂₈O₅
• Numéro CAS: 50-24-8
• Poids moléculaire : 360.44
• NACRES: NA.77
• PubChem Substance ID: 24898725
• UNSPSC Code: 12352200
• EC Number: 200-021-7
• MDL number: MFCD00003649
• Beilstein/REAXYS Number: 1354103
• Assay: ≥99%
• Form: powder

Propriétés

• Nom du produit: Prednisolone, ≥99%
• biological source: synthetic (organic)
• Quality Segment: 200
• sterility: non-sterile
• assay: ≥99%
• form: powder
• mp: 240 °C (dec.) (lit.)
• solubility: chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow
• originator: Johnson & Johnson
• shipped in: ambient
• storage temp.: room temp
• SMILES string: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
• InChI: 1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
• InChI key: OIGNJSKKLXVSLS-VWUMJDOOSA-N
• Gene Information: human ... AR(367), ESR1(2099), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866) ; mouse ... Nr3c1(14815) ; rat ... Ar(24208)

Description

General description

Prednisolone prevents protease activity in vitro. It stimulates myogenesis and inhibits apoptosis. Prednisolone is used to treat Duchenne muscular dystrophy (DMD), gout arthritis and chronic obstructive pulmonary disease (COPD) exacerbations.

Application

Prednisolone has been used for the Δ¹-dehydrogenation of hydrocortisone by gel entrapped arthrobacter simplex cells.

Biochem/physiol Actions

Prednisolone is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Analysis Note

Actual content given on label

Informations sur la sécurité

• Pictogrammes: GHS08
• Mot-clé: Danger
• Codes de danger: H360FD
• Mentions de précaution: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Gloves