P3338
Prostate Specific Antigen from human semen
buffered aqueous solution
Synonyme(s) :
Cancer-associated PSA, PSA
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A propos de cet article
Form:
buffered aqueous solution
Assay:
≥95% (SDS-GE)
Biological source:
human semen
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Service technique
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Laissez-nous vous aiderGeneral description
Prostate specific antigen (PSA) is a 28.43 kDa single-chain glycoprotein containing 237 amino acids, encoded by the kallikrein gene mapped to human chromosome 19. It is specifically expressed by human prostate tissue and is one of the highly abundant proteolytic enzyme expressed in the seminal fluid.
Application
Prostate Specific Antigen from human semen has been used:
- in microarray sandwich assay[1]
- in the preparation of sandwich immunosensor
- as a target protein to test composite organic−inorganic nanoparticle (COIN) and Alexa conjugates in a plate-binding assay
Biochem/physiol Actions
Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with chymotrypsin-like enzymatic activity. Circulating PSA exists in free and protease inhibitor-bound forms. Studying the ratios of free to inhibitor-bound forms may prove valuable in the diagnosis of prostate cancer.
Glycoprotein of the glandular kallikrein family
Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa.[2][3] Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M), and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.[3]
Packaging
Package size based on protein content
Physical form
Solution in phosphate buffered saline, contains 0.05-0.1% sodium azide with 50% glycerol
Analysis Note
Highly purified
1 of 1
Cet article | |||
|---|---|---|---|
| assay ≥95% (SDS-GE) | assay ≥99% (SDS-GE) | assay ≥95% (SDS-PAGE) | assay ≥99% (SDS-PAGE) |
| biological source human semen | biological source human semen | biological source human | biological source human |
| form buffered aqueous solution | form buffered aqueous solution | form lyophilized | form buffered aqueous solution |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −70°C | storage temp. −20°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. |
| Gene Information human ... KLK3(354) | Gene Information human ... KLK3(354) | Gene Information human ... KLK3(354) | Gene Information human ... KLK3(354), SERPINA3(12) |
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Classe de stockage
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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