P3235

Prostate Specific Antigen from human semen

buffered aqueous solution

• Synonyme(s) : Cancer-associated PSA, PSA
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00165544
• Form: buffered aqueous solution
• Assay: ≥99% (SDS-GE)
• Biological source: human semen

Propriétés

• biological source: human semen
• Quality Segment: 200
• assay: ≥99% (SDS-GE)
• form: buffered aqueous solution
• UniProt accession no.: P07288
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... KLK3(354)

Description

General description

Prostate specific antigen (PSA) is a 26kDa single-chain glycoprotein containing 237 amino acids, encoded by the kallikrein gene mapped to human chromosome 19. It is specifically expressed by human prostate tissue and is a highly abundant proteolytic enzyme expressed in the seminal fluid.

Biochem/physiol Actions

Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa. Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M) and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.

Glycoprotein of the glandular kallikrein family

Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with chymotrypsin-like enzymatic activity. Circulating PSA exists in free and protease inhibitor-bound forms. Studying the ratios of free to inhibitor-bound forms may prove valuable in the diagnosis of prostate cancer.

Physical form

Solution in 10 mM Tris, 0.1% sodium azide, pH 8.0

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable