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P2658

Sigma-Aldrich

Poly-L-lysine hydrochloride

suitable for cell culture, Mol wt 15,000-30,000

Synonyme(s) :

L-Lysine hydrochloride homopolymer

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About This Item

Numéro CAS:
26124-78-7
Numéro MDL:
MFCD00081870
Code UNSPSC :
12352209
eCl@ss :
32160406
Nomenclature NACRES :
NA.26

product name

Poly-L-lysine hydrochloride, mol wt 15,000-30,000

Forme

powder or solid

Poids mol.

15,000-30,000

Technique(s)

cell culture | mammalian: suitable

Couleur

white to light yellow

Application(s)

cell analysis

Température de stockage

−20°C

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Application

Poly-L-lysine hydrochloride has been used to coat glass slides and coverslips to facilitate cell attachment.
Poly-lysine with mol. wt. >70,000 is useful in promoting cell adhesion to solid substrates.

Actions biochimiques/physiologiques

L-Lysine is believed to prevent osteoporosis of bones, which is a characteristics of vascular calcification. Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex. L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Poly-L-lysine is considered as a biocompatible polymer and serves for the purpose of drug delivery across cell membrane. It is useful as one of the nanosized contrast agents in MRI (magnetic resonance imaging).

Remarque sur l'analyse

Molecular weight based on viscosity.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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The role of signaling pathways on proliferation and self-renewal of cultured bovine primitive germ cells
Sahare Mahesh
Reproductive medicine and biology, 14(1) (2015)
Multi-technique characterization of poly-L-lysine dendrigrafts-Cu(II) complexes for biocatalysis.
Rossi JC
Macromolecular Bioscience, 15(2), 275-290 (2015)
Mahesh Sahare et al.
Reproduction, fertility, and development, 28(12), 2039-2050 (2015-07-17)
Spermatogonial stem cells (SSCs) are unipotent in nature, but mouse SSCs acquire pluripotency under the appropriate culture conditions. Although culture systems are available for rodent and human germ-cell lines, no proven culture system is yet available for livestock species. Here
Archishman Ghosh et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(39), 19474-19483 (2019-09-12)
Membraneless organelles, corresponding to the droplet phase upon liquid-liquid phase separation (LLPS) of protein or protein-RNA mixtures, mediate myriad cellular functions. Cells use a variety of biochemical signals such as expression level and posttranslational modification to regulate droplet formation and
Understanding cerebral L-lysine metabolism: the role of L-pipecolate metabolism in Gcdh-deficient mice as a model for glutaric aciduria type I.
Posset R
Journal of inherited metabolic disease, 38(2), 265-272 (2015)
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