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P2371

Sigma-Aldrich

Pamidronate disodium salt hydrate

≥95% (NMR), solid

Synonyme(s) :

3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate

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About This Item

Formule empirique (notation de Hill):
C3H9NO7P2Na2 · xH2O
Numéro CAS:
57248-88-1
Poids moléculaire :
279.03 (anhydrous basis)
Numéro CE :
260-647-1
Numéro MDL:
MFCD11045314
Code UNSPSC :
12352200
ID de substance PubChem :
24724574
Nomenclature NACRES :
NA.77

Pureté

≥95% (NMR)

Forme

solid

Couleur

white

Pf

300 °C

Solubilité

H2O: 28 mg/mL

Auteur

Novartis

Température de stockage

2-8°C

Chaîne SMILES 

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

Clé InChI

TVQNUQCYOOJTMK-UHFFFAOYSA-L

Actions biochimiques/physiologiques

Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).

Caractéristiques et avantages

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Ratna Chatterjee et al.
British journal of haematology, 159(4), 462-471 (2012-09-13)
This study aimed to evaluate bone remodelling disorders in thalassaemia by using pamidronate (PD) infusion with or without hormone replacement therapy (HRT) as a diagnostic-therapeutic tool. In this prospective study, 24 adult thalassaemia major (TM) and 10 thalassaemia intermedia (TI)
Coralie Leblicq et al.
Pediatric blood & cancer, 60(5), 741-747 (2012-09-25)
Osteonecrosis (ON) is a severe complication of acute lymphoblastic leukemia (ALL) treatments. Recent studies suggest that bisphosphonates might reduce pain and loss of motor function in patients with ON. We assessed the effects of pamidronate compared to standard care in
Uncomplicated vaginal delivery in two consecutive pregnancies carried to term in a woman with osteogenesis imperfecta type I and bisphosphonate treatment before conception.
Chih-Ping Chen et al.
Taiwanese journal of obstetrics & gynecology, 51(2), 305-307 (2012-07-17)
Alexandre Loupy et al.
The Journal of clinical investigation, 122(9), 3355-3367 (2012-08-14)
Tight regulation of calcium levels is required for many critical biological functions. The Ca2+-sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium concentration by regulating parathyroid hormone (PTH) secretion. However, CaSR is also expressed in other organs, such as
Marcin Kos et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(6), 1010-1016 (2013-03-16)
Bacterial colonization of the denuded bone in bisphosphonate-related osteonecrosis of the jaw suggests that bisphosphonates increase bacterial adhesion and biofilm formation. This study evaluated the adhesion of gram-positive and gram-negative bacteria on hydroxyapatite coated with pamidronate, one of the most
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