P2116

Pirfenidone

≥97% (HPLC), powder, antifibrotic agent

• Synonyme(s) : 5-Methyl-1-phenyl-2-(1H)-pyridone
• Formule empirique (notation de Hill) : C₁₂H₁₁NO
• Numéro CAS: 53179-13-8
• Poids moléculaire : 185.22
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278625
• NACRES: NA.77
• MDL number: MFCD00866047
• Assay: ≥97% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Pirfenidone, ≥97% (HPLC)
• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• solubility: H₂O: >10 mg/mL at 60 °C (warming for 30 minutes), DMSO: >20 mg/mL
• originator: Shionogi
• SMILES string: O=C(C=CC(C)=C1)N1C2=CC=CC=C2
• InChI: 1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
• InChI key: ISWRGOKTTBVCFA-UHFFFAOYSA-N

Description

General description

Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) is a synthetic derivative of pyridine.

Application

Pirfenidone has been used:

• as a post-operative eye drop in rabbits to analyse its antifibrotic effect to improve glaucoma filtration surgery
• as an anti-scarring agent to examine whether it affects the foreign body reaction after glaucoma drainage device (GDD) implantation in a rabbit
• to test its antifibrotic potential in primary cultures of human orbital fibroblasts (hOFs)
• as tumor necrosis factor (TNFα) inhibitor to study its effect in hypoxia

Biochem/physiol Actions

Pirfenidone is used to treat idiopathic pulmonary fibrosis (IPF). It helps to decrease the weakening of lung function decline and ameliorate progression-free survival. Pirfenidone can repress the multiplication and contraction of collagen of human tenon′s fibroblasts.

Inhibits collagen production and fibroblast proliferation.

Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.

Features and Benefits

This compound was developed by Shionogi. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves