This product is intended for research use only. Unfortunately, a pharmaceutical grade (±)-Propranolol hydrochloride product is not offered. Unless otherwise stated this product is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
P0884
(±)-Propranolol hydrochloride
≥99% (TLC), powder, β-adrenoceptor antagonist
Synonyme(s) :
(±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride, DL-Propranolol hydrochloride
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A propos de cet article
Formule empirique (notation de Hill) :
C16H21NO2 · HCl
Numéro CAS:
Poids moléculaire :
295.80
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
206-268-7
MDL number:
Beilstein/REAXYS Number:
4164259
Assay:
≥99% (TLC)
Form:
powder
Le tarif et la disponibilité ne sont pas disponibles actuellement.
Service technique
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Laissez-nous vous aiderNom du produit
(±)-Propranolol hydrochloride, ≥99% (TLC), powder
Quality Segment
assay
≥99% (TLC)
form
powder
color
white
solubility
ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H2O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL
originator
AstraZeneca
storage temp.
2-8°C
SMILES string
Cl.CC(C)NCC(O)COc1cccc2ccccc12
InChI
1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H
InChI key
ZMRUPTIKESYGQW-UHFFFAOYSA-N
Gene Information
human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358)
General description
dissolve with heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.
Propranolol hydrochloride is easily soluble in ethanol and water.
Application
(±)-Propranolol hydrochloride has been used:
- to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat
- as a non-selective β- receptor blocker to reduce the arrhythmogenic events
- to study its effect on oxygen-induced retinopathy in mice
Biochem/physiol Actions
Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT1/5-HT2 serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Disclaimer
Shelf-life of the solid is at least four years if stored protected from the uptake of moisture.
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Cet article | |||
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| assay ≥99% (TLC) | assay - | assay - | assay - |
| form powder | form - | form liquid | form - |
| Quality Level 200 | Quality Level 300 | Quality Level 300 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-30°C | storage temp. −20°C | storage temp. - |
| solubility ethanol: 10 mg/mL, H2O: 50 mg/mL, DMSO: <14.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL | solubility - | solubility - | solubility - |
| originator AstraZeneca | originator - | originator - | originator - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Is this compound considered to be of pharmaceutical grade for use in animals?
1 answer-
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Bonjour, est-il possible de congeler une solution 10 mM de ce produit (P0884) en HBSS sans perte de ses propriétés moleculaires? Merci
1 answer-
Storing the solution at physiologic pH is not recommended, In aqueous solutions, propranolol decomposes with oxidation of the isopropylamine side-chain, accompanied by a reduction in pH and discoloration of the solution. Solutions of propranolol are most stable at pH 3. Propranolol decomposes rapidly in alkaline
solutions. Please see the link below to review a publication regarding the stability of this compound in solution:
https://academic.oup.com/ajhp/article-abstract/44/2/360/5196302?redirectedFrom=PDFHelpful?
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Could you please provide the solubility of product # P0884?
1 answer-
The chemical is soluble in water, ethanol, and DMSO. It is also soluble in (2-Hydroxypropyl)-β-cyclodextrin, making it compatible with in vitro and in vivo research. It is recommended to use C0926 in powder form or H5784 - (2-Hydroxypropyl)-β-cyclodextrin solution.
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What is the solution stability of the product P0884?
1 answer-
The solution stability of propranolol is as follows: In aqueous solutions, propranolol decomposes with oxidation of the isopropylamine side-chain, leading to a reduction in pH and discoloration of the solution. Solutions of propranolol are most stable at pH 3. According to Martindale references, propranolol decomposes rapidly in alkaline solutions.
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Is this compound a racemic mixture of the R and S enantiomers?
1 answer-
P0884 is a racemic mix of the D & L enantiomers of Propranolol hydrochloride.
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