P0040

PP1

≥98% (HPLC)

• Synonyme(s) : 4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine
• Formule empirique (notation de Hill): C₁₆H₁₉N₅
• Numéro CAS: 172889-26-8
• Poids moléculaire : 281.36
• Numéro MDL: MFCD01076570
• Code UNSPSC : 12352200
• ID de substance PubChem : 329819992
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Solubilité: DMSO: >20 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
• InChI: 1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
• Clé InChI: ZVPDNRVYHLRXLX-UHFFFAOYSA-N

Description

Application

PP1 has been used as:

• an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
• a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
• a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

Actions biochimiques/physiologiques

PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.

PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable