N7261

Nortriptyline hydrochloride

≥98% (HPLC), norepinephrine and serotonin inhibitor, powder

• Synonyme(s) : 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride, Desmethylamitriptyline hydrochloride
• Formule empirique (notation de Hill) : C₁₉H₂₁N · HCl
• Numéro CAS: 894-71-3
• Poids moléculaire : 299.84
• NACRES: NA.77
• PubChem Substance ID: 24278107
• UNSPSC Code: 41116107
• EC Number: 212-973-0
• MDL number: MFCD00058024
• Assay: ≥98% (HPLC)
• Form: powder

Propriétés

• Nom du produit: Nortriptyline hydrochloride, ≥98% (HPLC), powder
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: ethanol: 100 mg/mL, H₂O: soluble
• originator: Eli Lilly
• SMILES string: Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
• InChI key: SHAYBENGXDALFF-UHFFFAOYSA-N
• Gene Information: human ... HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

Description

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 3.4 nM) than the serotonin transporter (K_i = 161 nM). 5-HT₂ serotonin receptor antagonist.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H302
• Mentions de précaution: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Faceshields, Gloves