N6414

NN-DNJ

≥98% (HPLC)

• Formule empirique (notation de Hill) : C₁₅H₃₁NO₄
• Numéro CAS: 81117-35-3
• Poids moléculaire : 289.41
• NACRES: NA.77
• PubChem Substance ID: 329818665
• UNSPSC Code: 12352200
• MDL number: MFCD00905846
• Assay: ≥98% (HPLC)
• Form: solid

Propriétés

• assay: ≥98% (HPLC)
• form: solid
• solubility: DMSO: >10 mg/mL
• storage temp.: −20°C
• SMILES string: CCCCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
• InChI: 1S/C15H31NO4/c1-2-3-4-5-6-7-8-9-16-10-13(18)15(20)14(19)12(16)11-17/h12-15,17-20H,2-11H2,1H3/t12-,13+,14-,15-/m1/s1
• InChI key: FTSCEGKYKXESFF-LXTVHRRPSA-N

Description

Biochem/physiol Actions

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone.

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H319
• pcodes: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves