N6252

Norharmane

≥98% (TLC), crystalline, monoamine oxidase inhibitor

• Synonyme(s) : β-Carboline, 9H-Pyrido[3,4-b]indole
• Formule empirique (notation de Hill) : C₁₁H₈N₂
• Numéro CAS: 244-63-3
• Poids moléculaire : 168.19
• NACRES: NA.77
• PubChem Substance ID: 24897776
• UNSPSC Code: 12352200
• EC Number: 205-959-0
• MDL number: MFCD00004956
• eCl@ss: 32160701
• Form: crystalline

Propriétés

• Nom du produit: Norharmane, crystalline
• form: crystalline
• Quality Segment: 200
• color: light yellow
• storage temp.: 2-8°C
• SMILES string: c1ccc2c(c1)[nH]c3cnccc23
• InChI: 1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
• InChI key: AIFRHYZBTHREPW-UHFFFAOYSA-N
• Gene Information: human ... IKBKB(3551) ; rat ... Gabra2(29706)

Description

General description

Norharmane is an alkaloid widely present in living organisms and can also be chemically synthesized. It is a β-carboline derivative composed of indole and pyridine.

Application

Norharmane has been used:

• as a β-carboline to study its effect on nigrostriatal dopamine (DA) neurons
• as an internal standard in gas chromatography-mass spectrometry (GC-MS) analyses using Conidiobulus coronatus filtrates
• as a β-carboline-3-carboxylic acid N-methylamide (CMA) analog to study its binding ability with Mcm2-7 (minichromosome maintenance)

Biochem/physiol Actions

Inhibitor of indoleamine 2,3-dioxygenase (IDO).

Norharmane and its derivative exhibit anti-cancer properties. It acts as a monoamine oxidase (MAO) inhibitor and might benefit Parkinson′s disease (PD). High levels of β-carboline in plasma are found in PD.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• WGK: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): Eyeshields, Gloves, type N95 (US)