N5636

3-Nitropropionic acid

≥97% (HPLC), powder or crystals, mitochondrial complex II inhibitor

• Formule linéaire : O₂N(CH₂)₂CO₂H
• Numéro CAS: 504-88-1
• Poids moléculaire : 119.08
• Numéro Beilstein : 1759889
• Numéro CE : 208-003-0
• Numéro MDL: MFCD00007406
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278593
• Nomenclature NACRES : NA.77

Propriétés

• product name: 3-Nitropropionic acid, ≥97%
• Source biologique: synthetic
• Pureté: ≥97%
• Forme: powder or crystals
• Couleur: white to light yellow
• Pf: 68-70 °C (lit.)
• Solubilité: alcohol: may be light yellow 100 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(CC[N+]([O-])=O)=O
• InChI: 1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
• Clé InChI: WBLZUCOIBUDNBV-UHFFFAOYSA-N

Description

Application

3-Nitropropionic acid has been used:

• to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
• to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
• as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines

Actions biochimiques/physiologiques

Administering 3-nitropropionic acid (3-NP) to the inner ear can stimulate sensorineural hearing loss. It serves as an irreversible inhibitor of mitochondrial complex II.

Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P301 + P330 + P331 + P310
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges