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N3908

Sigma-Aldrich

Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit

enhanced validation

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

NGFR Antibody - Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit, Ngfr Antibody

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About This Item

Numéro MDL:
MFCD00675539
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

rat

Validation améliorée

functional assay
Learn more about Antibody Enhanced Validation

Technique(s)

immunohistochemistry (frozen sections): 1:10,000 using rat brain
indirect immunofluorescence: 1:500 using NGF-treated PC12 cells
microarray: suitable
western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells

Numéro d'accès UniProt

P07174

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

rat ... Ngfr(24596)

Description générale

Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.
Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.

Immunogène

synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.

Application

Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:
  • immunoprecipitation
  • immunocytochemistry
  • immunohistochemistry
  • immunoblotting

Actions biochimiques/physiologiques

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Yan Chen et al.
Medical science monitor : international medical journal of experimental and clinical research, 21, 3608-3615 (2015-11-22)
Alzheimer's disease (AD) is the most common type of dementia. It causes progressive brain disorder involving loss of normal memory and thinking skills. The transplantation of neural stem cells (NSCs) has been reported to improve learning and memory function of
C O Hanemann et al.
Neuropathology and applied neurobiology, 32(6), 605-614 (2006-11-07)
The NF2 gene encodes the tumour suppressor protein merlin. The mutation of a single allele of this gene causes the autosomal dominantly inherited disease neurofibromatosis type 2 (NF2), which is characterized mainly by vestibular schwannoma carrying a second hit mutation.
Myeongjeong Choo et al.
Nature communications, 8(1), 195-195 (2017-08-05)
Elimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs). A single CF is strengthened whereas the other CFs are eliminated
Soheila Pourkhodadad et al.
Cell journal, 21(2), 220-228 (2019-03-03)
Traumatic spinal cord injury (SCI) is considered one of the most devastating injuries leading to neuronal disruption. Olfactory ensheathing cells (OECs) and minocycline have been shown to promote locomotor function after spinal cord injury. In this study, we have tested
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