N3398

S-Nitroso-N-acetyl-DL-penicillamine

≥97%, Nitric oxide donor, powder

• Synonyme(s) : N-Acetyl-3-(nitrosothio)-DL-valine, S-Nitroso-N-acetylpenicillamine, SNAP
• Formule empirique (notation de Hill) : C₇H₁₂N₂O₄S
• Numéro CAS: 67776-06-1
• Poids moléculaire : 220.25
• UNSPSC Code: 12352116
• PubChem Substance ID: 24278584
• NACRES: NA.32
• MDL number: MFCD00272624

Propriétés

• Nom du produit: S-Nitroso-N-acetyl-DL-penicillamine, ≥97%, powder
• Quality Segment: 300
• assay: ≥97%
• form: powder
• color: faint green to very dark green
• solubility: H₂O: ≥2 mg/mL, DMSO: ≥20 mg/mL, clear (faint green to very dark green)
• storage temp.: −20°C
• SMILES string: CC(=O)NC(C(O)=O)C(C)(C)SN=O
• InChI: 1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)
• InChI key: ZIIQCSMRQKCOCT-UHFFFAOYSA-N

Description

Application

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) has been used:

• as a positive control in nitrite generation assay.
• to block the activity of endogenous transglutaminase (TG2).
• in proliferation assays to generate nitric oxide (NO) in cell cultures.

Biochem/physiol Actions

NO donor; vasodilator, smooth muscle relaxant, lymphocyte activator. Activates soluble guanylyl cyclase.

SNAP, a nitrosothiol derivative, releases nitric oxide (NO.) under physiological conditions thus making it a useful tool for studying pharmacological and physiological actions of NO. Because of its NO releasing properties SNAP is a potent vasodilator in vitro and in vivo and is less prone to produce pharmacological tolerance.

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• EPI (équipement de protection individuelle): dust mask type N95 (US), Eyeshields, Gloves
• Pictogrammes: GHS08,GHS05
• Mot-clé: Danger
• Codes de danger: H315,H318,H341
• Mentions de précaution: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Dam. 1 - Muta. 2 - Skin Irrit. 2