MAK110

MTP Activity Assay Kit

Supplied by Roar Biomedical, Inc.

• Synonyme(s) : MTTP Activity Assay Kit, Microsomal triglyceride transfer protein activity assay kit
• NACRES: NA.84
• UNSPSC Code: 12161503

Propriétés

• usage: sufficient for 100 fluorometric tests
• application(s): pharmaceutical
• detection method: fluorometric
• relevant disease(s): cardiovascular diseases
• storage temp.: 2-8°C
• Gene Information: human ... MTTP(4547)

Description

General description

Microsomal triglyceride transfer protein (MTP), a membrane-bound protein present in the liver, plays an important role in the assembly and secretion of very low density lipoprotein (VLDL). MTP is also necessary for assembly and secretion of chylomicrons by the intestine. This protein facilitates the transfer of triglyceride (TG), cholesteryl ester (CE) and phosphatidylcholine (PC) between phospholipid surfaces. Mutation in the MTP gene leads to abetalipoproteinemia.

Application

Suitable for measuring microsomal [triglyceride] transfer protein (MTP) activity in cell lysates or tissue homogenates, or for screening MTP activity inhibitors.

MTP Activity Assay Kit has been used to measure the activity of microsomal triglyceride transfer protein (MTP).

Biochem/physiol Actions

The MTP Activity Assay Kit is a sensitive, homogeneous fluorometric assay useful for continuous measurement of MTP activity in cell lysate or tissue homogenate. This kit includes proprietary substrates that enable the detection of MTP-mediated transfer of neutral lipid. The transfer activity results in an increase in fluorescence intensity (λ_Ex=465 nm/λ_Em=535 nm).

Features and Benefits

Compatible with high-throughput handling systems.

Analysis Note

Learn more about Roar Assay Kits for Studies in Lipoprotein Metabolism.

Informations sur la sécurité

• Classe de stockage: 10 - Combustible liquids