M5435

6-Methyl-2-(phenylethynyl)pyridine hydrochloride

≥98% (HPLC)

• Synonyme(s) : MPEP hydrochloride
• Formule empirique (notation de Hill): C₁₄H₁₁N · HCl
• Numéro CAS: 219911-35-0
• Poids moléculaire : 229.70
• Numéro MDL: MFCD02262119
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278557
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white to light tan
• Solubilité: DMSO: 10 mg/mL, clear
• Température de stockage: room temp
• Chaîne SMILES: Cl.Cc1cccc(n1)C#Cc2ccccc2
• InChI: 1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
• Clé InChI: PKDHDJBNEKXCBI-UHFFFAOYSA-N
• Informations sur le gène: human ... GRIN2B(2904) , GRM5(2915) ; rat ... Grm5(24418)

Description

Description générale

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) codes for N-methyl d-aspartate receptor subtype 2B (GluN2B). It belongs to the N-methyl-D-aspartate receptor (NMDAR) gene family. It is located on chromosome 12p13.1.

Application

6-Methyl-2-(phenylethynyl)pyridine hydrochloride has been used to investigate whether 3, 4 (±) methylenedioxymethamphetamine (MDMA) could influence self-renewal via the mGlu5 receptor in mouse embryonic stem cells (mESCs).

Actions biochimiques/physiologiques

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) plays an important role in the growth of neurons and is highly essential for learning and memory. GRIN2B mutation is associated with neuropsychiatric and developmental disorders like schizophrenia, Parkinson′s disease and bipolar disorder. MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride) is used to treat Alzheimer′s disease (AD).

Highly selective, non-competitive mGluR₅ metabotropic glutamate receptor antagonist.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)