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M3821

Sigma-Aldrich

Anti-Myelin Basic Protein (MBP) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-MBP

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About This Item

Numéro MDL:
MFCD01322361
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 17-22 kDa (isoform)
antigen ~22 kDa (isoform)
antigen ~33 kDa (isoform)

Espèces réactives

rat, human, mouse

Concentration

~1 mg/mL

Technique(s)

flow cytometry: 1:200-1:500
immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000

Numéro d'accès UniProt

P02686

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)

Description générale

Myelin Basic Protein (MBP) is a hydrophilic protein that is expressed mainly in oligodendrocytes. It has a pivotal role in myelination of nervous system, signaling pathways prior to myelination and remyelination processes after neural injury. Anti-myelin basic protein (MBP) antibody can be used in western blotting and flow cytometry. Rabbit anti-myelin basic protein antibody reacts specifically with myelin basic protein of mouse, rat and human.
Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of the myelin sheath and is highly expressed in central nervous system (CNS).

Immunogène

synthetic peptide corresponding to residues 102-116 of human Myelin Basic Protein.

Application

Anti-Myelin Basic Protein (MBP) antibody produced in rabbit has been used in:
  • indirect immunolabeling
  • immunohistochemistry.
  • Western Blotting.
Anti-myelin basic protein (MBP) antibody (diluted 1:200) can be used as a primary antibody in double fluorescence labeling. It can also be used to detect myelin basic protein using immunoblotting.

Actions biochimiques/physiologiques

Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP functions as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.

Forme physique

solution in phosphate buffered saline, containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Neuroglial Cells in Long-Term Primary Cultures from the Gilthead Seabream (Sparus Aurata L.): New Functional In Vitro Model from Bony Fish Brain
Centoducati, et al.
Italian Journal of Animal Science, 12 (2013)
H Inouye et al.
Journal of neuroscience research, 28(1), 1-17 (1991-01-01)
To explain how the myelin proteins are involved in the organization and function of the myelin sheath requires knowing their molecular structures. Except for P2 basic protein of PNS myelin, however, their structures are not yet known. As an aid
Neurotropin? Accelerates the Differentiation of Schwann Cells and Remyelination in a Rat Lysophosphatidylcholine-Induced Demyelination Model
Matsuoka H, et al.
International Journal of Molecular Sciences, 19 (2018)
C M Deber et al.
Clinical biochemistry, 24(2), 113-134 (1991-04-01)
Multiple sclerosis (MS) and a number of related distinctive diseases are characterized by the active degradation of central nervous system (CNS) myelin, an axonal sheath comprised essentially of proteins and lipids. These demyelinating diseases appear to arise from complex interactions
Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.
Ding Y, et al.
PLoS ONE, 9 (2014)
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