M2727

Mexiletine hydrochloride

≥98% (GC), powder, sodium channel blocker

• Synonyme(s) : 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride, 1-(2,6-Xylyloxy)-2-aminopropane hydrochloride
• Formule empirique (notation de Hill) : C₁₁H₁₇NO · HCl
• Numéro CAS: 5370-01-4
• Poids moléculaire : 215.72
• NACRES: NA.77
• PubChem Substance ID: 24278542
• UNSPSC Code: 12352200
• EC Number: 250-825-7
• MDL number: MFCD00216024
• Assay: ≥98% (GC)
• Form: powder

Propriétés

• Nom du produit: Mexiletine hydrochloride, powder
• assay: ≥98% (GC)
• Quality Segment: 200
• form: powder
• color: white to off-white
• solubility: methanol: 50 mg/mL
• originator: Boehringer Ingelheim
• storage temp.: 2-8°C
• SMILES string: Cl[H].CC(N)COc1c(C)cccc1C
• InChI: 1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
• InChI key: NFEIBWMZVIVJLQ-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

Mexiletine is a class I B antiarrhythmic and an analog of lidocaine. It has shelf life of 10-12 hours and is metabolized in liver and eliminated post reduction, oxidation deamination or conjugation.

Application

Mexiletine hydrochloride has been used as a sodium channel blocker:

• expressed in chinese hamster ovary cells
• in human embryonic kidney (HEK) cells for whole cell patch-clamp studies
• electrophysiology studies in HEK cells expressing Nav1.7 protein

Biochem/physiol Actions

Mexiletine is a potent sodium channel blocker. It is a cardiac antiarrhythmic and is used as an adjuvant in headache and neuropathic pain Mexiletine is used for treating myotonia in sodium channelopathies and reduces the cardiac action potential depolarization but shows no impact on atrial refractoriness. Its inhibitory effect on sodium channels is effective in treating potassium aggravated myotonia.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mot-clé: Warning
• Codes de danger: H302
• Mentions de précaution: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable